Oncology Principal Investigator

Company: Plexus Partners
Location: San Francisco
Posted on: February 26, 2026

Job Description:

Job Description Oncologist / Principal Investigator - Clinical Research leadership Location: Los Angeles, CA (relocation assistance provided) Employment Type: Full-Time, On-Site Salary : $750k base salary, bonuses and incentives Overview We are representing an exceptional research-focused oncology organization seeking a Principal Investigator (PI) to oversee a highly experienced clinical team and drive breakthrough studies with biotech sponsors. This is a full-time, research-only role , offering the opportunity to guide cutting-edge oncology trials in a fast-growing, data-driven clinical environment. The position is ideal for an oncologist who wants to transition from purely clinical practice into a leadership role at the intersection of science, medicine, and industry , helping advance next-generation cancer therapies. Key Responsibilities Serve as the Principal Investigator for oncology trials across multiple modalities and sponsors. Provide medical oversight, ensure patient safety, and maintain protocol compliance and data integrity. Supervise and mentor sub-investigators, nurse practitioners, and clinical operations staff. Collaborate closely with sponsors, CROs, and internal study teams to drive enrollment and site performance. Support scientific and operational strategy, SOP refinement, and future site development. Participate in investigator meetings, safety reviews, and regulatory inspections. Ideal Candidate MD or DO with board certification or eligibility in Hematology/Oncology (or related discipline). Licensed or license-eligible to practice medicine in California. 1–5 years post-fellowship experience (early-career attendings encouraged to apply). Demonstrated clinical excellence and the ability to manage oncology patients in a research setting. Prior Sub-I or PI experience preferred but not required — full GCP training and mentorship provided. Strong communication skills, collaborative mindset, and enthusiasm for research and innovation. Must be committed to a full-time, on-site position. Why This Opportunity Exceptional Organization — culture of scientific rigor, integrity, and collaboration. Exposure to Cutting-Edge Oncology Programs — work on next-generation therapeutic approaches. Leadership Trajectory — opportunity to expand into multi-site or network-level leadership. Competitive Compensation — highly attractive package with relocation and performance incentives. This search is being managed exclusively by Plexus Partners. Interested candidates can submit a CV or express interest in confidence to: elliot@plexus-partners.com

Keywords: Plexus Partners, Dublin , Oncology Principal Investigator, Science, Research & Development , San Francisco, California